Exogenous itaconate addition in apolipoprotein E-deficient (Apoe−/−) mice suppressed the initiation and progression of AAA and downstream inflammatory protein though Irg1 deficiency reverted the impact of inhibitory. Overexpression of Keap1 or transferred Cys151S mutant Keap1 vector also abolished the activation of Nrf2 induced by itaconate.Inf
New scientific studies have implicated the Hippo pathway and its transcriptional effectors YAP and TAZ as essential for fibroblast activation and tissue fibrosis. To test the specific and sufficient roles for TAZ in driving autonomous fibroblast activation, we cultured NIH3T3 fibroblasts expressing a doxycycline-inducible nuclear-localized mutant o
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